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血清表皮生长因子与子宫肌瘤生长的关系 |
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李美蓉 李伯阳 牛战琴 李明娥
【摘要】 目的 探讨血清表皮生长因子(EGF)与子宫肌瘤生长及其与雌激素和孕激素的关系。方法 对40例子宫肌瘤患者(观察组)，于月经周期增殖期或分泌期，用放射免疫法测定血清EGF水平；采用酶标记单克隆抗体法测定雌二醇(E2)和孕酮(P)水平。20例健康妇女作为对照组。 结果观察组分泌期EGF［(1.86±0.40) μg/L］、E2［(329.49±197.63) pmol/L］和P［(40.10±17.17) nmol/L］水平明显高于对照组(P＜0.05)；观察组分泌期EGF水平明显高于增殖期［(1.39±0.42) μg/L］(P＜0.05)；EGF水平随子宫增大而上升。EGF水平与E2无相关关系(r=0.25，P＞0.05)，与P呈正相关关系(r=0.71，P＜0.005)。E2和P同时升高时，EGF水平最高；单纯P增高时，EGF水平高于单纯E2增高时；E2和P均低时，则EGF水平也最低。结论 EGF与子宫肌瘤的生长有关，可能对肌瘤细胞和子宫肌细胞均有促分裂增殖的作用。E2可能诱发EGF产生，但作用不如P强，进入分泌期后，在P的作用下EGF水平可进一步升高。
【关键词】 子宫肿瘤；表皮生长因子-尿抑胃素；雌激素类；孕酮；平滑肌瘤
Relationship between Serum Epidermal Growth Factor and Uterine Leiomyoma
LI Meirong, LI Boyang, NIU Zhanqin, et al.
Department of Obstetrics and Gynecology, Frist Hospital of Shanxi Medical University, Taiyuan 030001, China
【Abstract】 Objective To study the effects of epidermal growth factor (EGF) on uterine leiomyoma and the relationship of EGF and estrogen, progesterone. Methods Fourty patients with uterine leiomyoma and twenty normal women were studied. Serum EGF level was determinted by radioimmunoassay, estradiol (E2) and progesterone (P) levels were measured by enzyme marked monoclonal antibody assay. Results Serum EGF、 E2 and P levels in observed group were singnificantly higher than those in control group during secretive phase (P＜0.005). The serum EGF level in observed group during prolifrative phase was singnificantly higher than that of secretive phase (P<0.05). The serum EGF level increased while uterus enlarged; EGF wasn′t related to E2 (r=0.25, P>0.05) and was related to P (r=0.71, P＜0.005). The EGF level was the highest when E2 and P both increased. Conclusion EGF has the effect on growth of uterine leiomyoma. It is possible that EGF secretion can be stimulated by E2 and the effect of P is stronger than E2.
【Key words】 Uterine neoplasms; Epidermal growth factor-urogastrone; Estrogens[1] [2] [3] 下一页
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