表皮生长因子受体表达与预测葡萄胎恶变相关性研究

　　【关键词】 葡萄胎 妊娠滋养层肿瘤 表皮生长因子受体 免疫组织化学

　　INVESTIGATION INTO THE RELATIONSHIP BETWEENTHE EXPRESSION OF EPIDERMAL GROWTH FACTORRECEPTOR AND GESTATIONAL TROPHOBLASTIC DISEASE.Xie Ling　(Department of Gynecology ， Women and Children Hospital)Abstract Objective To investigate the expression of epidermal growth factor receptor (EGFR) in gestational trophoblastic disease (GTD) and its value in the prognosis of hydatidiformmole.　Methods　105 cases of GTD tissues and 20 cases of normal chorion villi specimens were examined by immunohistochemical techniques using EGFR monoclonal antibody.　Results　Stain for EGFR was detected in all cell types of trophoblasts in GTD tissues and normal chorion villi. In syncytiotrophoblasts (ST)，expression of EGFR protein were strong in GTD tissues and normal chorion villi，and there was no significant differences observed among them.In cytotrophoblasts (CT)，expression of EGFR protein was significantly higher in normal chorion villi and non-malignant transforming groups (NMTG) as compared to those in malignant transforming groups (MTG)，invasive hydatidiformmole and choriocarcinoma (P<0.05， P<0.05，and P<0.05，respectively).Furthermore，expression of EGFR protein was significantly higher in MTG as compared with that of invasive hydatidiform mole and choriocarcinoma groups(P<0.05, and P<0.05, respectively).There was no significant difference in EGFR protein expression between invasive hydatidiform mole and choriocarcinoma groups(P>0.05).Size of the uterus and presence of the lute

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