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大剂量芬太尼麻醉对家兔不同声强下脑干听觉诱发电位及40Hz听觉稳态电位的影响 |
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张祥晶 张炳熙 彭世春 吕建忠 郭连生 杨宜林 张燕婉
摘要 目的：为探讨合理的麻醉深度监测指标，观察了大剂量芬太尼麻醉对24例家兔脑干听觉诱发电位（BAEP）及40Hz听觉稳态电位（40Hz-ASSR）的影响。方法：实验组分3次静注总量90μg／kg芬太尼，对照组注射等量生理盐水。于首次给药前及给药后5、25、45分钟测定80、60、50dBnHL下BAEP及120、110、100dBnHL下40Hz-ASSR波形变化及阈值强度。结果：随着血浆芬太尼浓度逐渐升高，各声强下BAEPⅠ、Ⅱ、Ⅳ波潜伏期，振幅，Ⅰ-Ⅱ、Ⅱ-Ⅳ、Ⅰ-Ⅳ波间期无明显改变，各测定点阈值强度无改变；而各声强下40Hz-ASSRPa、Pb波潜伏期逐渐延长，振幅下降，各测定点阈值强度逐渐增高。结论：与BAEP相比，120、110、100dBnHL声强下40Hz-ASSR是监测大剂量芬太尼麻醉深度的可靠指标。
关键词 芬太尼 脑干听觉诱发电位 40Hz听觉稳态电位 麻醉深度
Effects of High Dose Fentanyl on Brain-stem Auditory Evoked Potentials and on 40 Hz-AuditorySteady State Responses under Different of Sound Stimulus Intensity Levels in Rabbits
Zhang Xiangjing，Zhang Bingxi，Peng Shichun，et al
Department of Anesthesiology，Beijing TongRen Hospital， Capital University of Medical Science100730
Abstract Objective：To explore the objective monitoring index of anesthesia depth，we studied respectively the effects of high dose fentanyl anesthsia on brain stem auditory evoked potentials（BAEP）and on 40Hz-auditoy steady state responses （40Hz-ASSR）in twenty-four rabbits．Methods：After intravenous injection of a cumulative dose of 90μg／kg fentanyl（three equal bolus injections）in study group and equivalent volumes of saline in control group，the changes of BAEP at the sound stimulus intensity levels（SSIL） of 80，60，50dBnHL，40Hz-ASSSR under SSIL of 120、110、100dBnHL and their auditory evoked potentials thresholds（AEPT）were measured respectively before the first bolus of fentanyl and at 5，25，45 min after the first bolus of fentanyl．Results：The latencies，amplitudes of wave Ⅰ，Ⅱ，Ⅳ and interwave Ⅰ-Ⅱ，Ⅱ-Ⅳ，Ⅰ-Ⅳ of BAEP and AEPT of BAEP at three different SSIL had no change with the increasing of serum fentanyl concentrations，and the latencies of wave Pa， Pb of 40Hz-ASSR at above three SSIL were progressively increasing with the increasing of serum fentanyl concentrations，at sametime， decreasing in the amplitudes and increasing in the AEPT．Conclusion：40Hz-A[1] [2] 下一页
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