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自发性高血压大鼠肠系膜动脉的非肾上腺素 非胆碱能血管扩张反应 |
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张建新 李兰芳 王素敏 陈素青 刘赤平 吴树勋
摘 要 目的：观察L－硝基精氨酸(L－NA）对神经刺激所致正常和自发性高血压大鼠(SHR)离体肠系膜动脉反应的影响作用。方法：采用离体血管实验方法，测定肠系膜动脉条的等容张力变化。结果：NO(－氧化氮)合成抑制剂L－NA显著增强电和化学(烟碱)刺激引起的正常大鼠肠系膜动脉收缩反应(P＜0.01)，此增强作用可被NO供体L－精氨酸取消(P＜0.01)，L－NA对电和化学刺激所致SHR动脉收缩效应无明显影响(P＞0.05)。L－NA对血管神经末梢去甲肾上腺素的释放及对外源性去甲肾上腺素的血管收缩后作用均无明显影响。正常大鼠动脉条用哌唑嗪处理并用PGF2α部分收缩后电和化学刺激均引起血管舒张，此舒张效应可被L－NA抑制，该抑制作用又可为L－精氨酸逆转(P＜0.01)。但电和化学刺激SHR动脉条均未引起明显的血管舒张反应，而且也不受L－NA的影响。结论：神经刺激引起的正常大鼠动脉舒张效应由NO中介，系非肾上腺素、非胆碱能血管扩张神经；神经刺激SHR动脉无明显血管舒张反应也与其非肾上腺素、非胆碱能血管扩张神经功能低下有关，后者可能系SHR的发病机制之一。
主题词 精氨酸；一氧化氮；高血压；血管舒张；神经组织
Non-adrenergic,non-cholinergic innervation in normotensive
and spontaneously hypertensive rats
ZHANG Jian-Xin,LI Lan-Fang,WANG Su-Min,CHEN Su-Qing,LIU Chi-Ping,WU Shu-Xun
Hebei Academy of Medical Sciences,Shijiazhuang(050021)
Abstract AIM：To observe the action of NG－nitro－L－arginine(L－NA) on effects of nerve stimulation on isolated mesenteric artery strips of normotensive and spontaneously hypertensive rats(SHR).METHODS：The isometric tension of endothelium-denuded isolated mesenteric artery strips from rats were measured by a forcedisplacement transducer.RESULTS:Normotensive rat mesenteric artery strips responed to transmural electrical stimulation and nicotine with a contraction,which was potentiated by L-NA,a nitric oxide(NO)synthesis inhibitor.L-arginine reversed the potentiation.The contraction induced by transmural electrical stimulation and nicotine was not influenced by L-NA in SHR.Release of norepinephrine evoked by adrenergic nerve stimulation and contractile response to exogenous norepinephrine were not increased by L-NA.In the normotensive rat endothelium-denude artery strips treated with prazosin,electrical stimulation and nicotine produced a relaxation,which were abolished by L-NA.The inhibitions were antagonized by L-arginine However,in the SHR endothelium-denude artery strips,electrical stimulation and nicotine did not produce a relaxatio[1] [2] 下一页
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