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利多卡因对兔内毒素性肺损伤晚期的治疗效应 |
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李永荣 郭贵林 尹逊华 安 虹 姚德厚
摘 要 目的：观察利多卡因对兔注射内毒素24h后的治疗效应。方法：用日本大耳白兔随机分为对照组、大肠杆菌内毒素(ET)组和ET注入后24h+利多卡因(lidocaine)组。用酶联免疫法和硫代巴比妥酸反应法测量血浆和支气管肺泡灌洗液(BALF)中TNFα和MDA含量。结果：免静注ET后24h再静注利多卡因，于静注利多卡因后3、5h，血浆和BALF中TNFα和MDA含量显著降低，血中性粒细胞数目明显回升。肺湿干重比值和BALF中性粒细胞数、白蛋白含量、C3a\,C5a浓度无明显变化。结论：内毒素肺损伤后(注ET后24h)用lidocaine仍可抑制脂质过氧化反应和炎症介质的释放。对肺损伤晚期仍有一定的治疗作用。
主题词 内毒素类；肺；利多卡因；呼吸窘迫综合征
Therapeutic effects of lidocaine on the later phase
of endotoxin-induced lung injury in rabbits
LI Yong-Rong, YAO De-Hou, GUO Gui-Lin, YIN Xun-Hua, AN Hong
Chengdu Army General Hospital, Chengdu(610083)
Abstract AIM：To investigate the therapeutic effects of lidocaine on the later phase of endotoxin-induced lung injury in rabbits. METHODS：Japan white rabbits were randomly assigned to receive one of the three treatments: infusion of saline (control group), infusion of Escherichia coli endotoxin (ET group), the later phase of endotoxin-induced lung injury with lidocaine treatment (ET+lidocaine group). The tumor necrosis factor-α(TNFα) and malondialdehyde (MDA) contents in plasma and bronchoalveolar lavage fluid (BALF) were analysed by ELISA and Satrh TBA method respectively.RESULTS：The later phase of endotoxin-induced lung injury with lidocaine atteuated the changes of TNFα and MDA contents in plasma and BALF. The wet-to-dry weight ratio in the lung did not change and neutropils cell counts, albumin, C3a and C5a concentration in BALF did not change significantly as compared with ET group. CONCLUSION：In the later phase of endotoxin-induced lung injury lidocaine still inhibited lipoperoxidation and releases of the inflammatory mediators, and attenuated endotoxin-induced lung injury in rabbits.
MeSH Endotoxins; Lung; lidocaine; Respiratory distress syndrome
中性粒细胞在肺内聚积，脂质过氧化和炎症介质的释放在内毒素性肺损伤中起着重要作用［1］。利多卡因(lidocaine)能抑制中性粒细胞释放氧自由基和炎症介质［2，3］，稳定细胞膜功能［4］，lidocaine是否能通过抑制氧自由基的产生和炎症介质的释放来防治内毒[1] [2] [3] 下一页
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