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二甲基甘氨酸对脊髓神经元的作用 |
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EFFECT OF DIMETHYL GLYCINE ON SPINAL NEURONS
Anitha Oommen,Shanthakumar Thomas Oommen
（Fr. Muller s Institute, Mangalore 575 002, India,）
Muddanna S Rao
（Kasturba Medical College, Manipal 576 119,India）
【Abstract】 N, N-dimethyl glycine(DMG),a food supplement, is claimed to be non
-toxic and is known for its immunoprotective and stamina building property. It improves CNS functions,mainly speech in autistic children, causes behavioral improv
ement and decreases seizures. To study its effect on the neurons on the ventral half of the cervical enlargement of the spinal cord, DMG dissolved in distilled water was given to 21 day old albino mice at a dose of 20mg/kg body weight per day for 30 days. The ventral half of the cervical enlargement of the spinal cord was studied morphologically. The results showed a significant decrease in the neuron count in the 15-25 micron range in the DMG-treated mice. No significant change was observed in the area of gray matter or white matter or total area. Neurons having a diameter of more than 25 microns showed no change in the cell count.These results suggest a cytotoxic damage caused by DMG.
【Key words】 Dimethyl glycine; Neuronal change; Spinal neurons
【 CLC number】R322.85 【Document code】A
【Article ID】0529-1356(2000)02-129
Introduction
N,N-dimethyl glycine, a nutrient［1］,a methylated glycine, also known as pangamic acid and calcium pangamate, was once considered to be Vitamin B-15. However dietary deficiency of DMG does not cause any known disease［2］. DMG is present in low levels in meat, seeds and grains［3］. It is claimed to improve speech and behavioral patterns in mentally retarded and autistic children. It is claimed to be non-toxic and with no undesirable side effects［4］. It has been described as a new horizon in therapeutics［5］.
DMG is known to improve immunity. It increases lymphocyte proliferation, stimul[1] [2] [3] 下一页
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