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利巴韦林累积剂量对基因1型慢性丙型肝炎患者病毒学应答率的影响 |
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ribavirin cumulative dose:>97%,80%-97%,60%-79%and<60%of standard cumulative dose.The relationship between ribavirin cumulative dose and virological response rates was studied.Data as analyzed by chisquare test or F test.Results The incidence of ribavirin cumulative dose<97%was 43.1%(97/225),which was higher than peginterferon alfa-2a(27.1%,61/225)(x2=12.641,P=0.001).The sustained virological response rate(SVR)was 27.8%(5/18)in group of ribavirin cumulative dose <60%,which was much lower than those in groups of ribavirin cumulative dose>97%(65.6%,84/128),80%-97%(60.5%,26/43),60%-79%(58.3%,21/36)(x2=9.538,P=0.023).The relapse rate was 61.5%(8/13)in group of ribavirin cumulative dose<60%,which was significantly higher than those in groups of ribavirin cumulative dose>97%(20.0%,21/105),80%-97%(23.5% ,8/34),60%-79%(27.6%,8/29)(x2=10.837,P-0.013).Among patients achieved rapid virological response(RVR),SVR in groups of ribavirin cumulative dose>97%,80%-97%,60%-79%and<60 % of standard dose were 92.0%(23/25),88.9%(8/9),85.7%(6/7)and 75.0%(3/4),respectively(x2=1.098,P=0.778).Conclusiom Mlid reduction of ribavirin dose not affect SVR of genotype 1 HCV infected patients.However,the relapse rate is high and SVR is low in patients treated with ribavirin cumulative dose<60% of standard dose.
Keywords：Hepatitis C,chronic;Ribavirin;Dose-response relationship,drug;Genes,viral
作者单位：孙丽杰（150086,哈尔滨医科大学附属第二医院感染病科）
于建武（150086,哈尔滨医科大学附属第二医院感染病科）
康鹏（150086,哈尔滨医科大学附属第二医院感染病科）
赵勇华（150086,哈尔滨医科大学附属第二医院感染病科）
颜炳柱（150086,哈尔滨医科大学附属第二医院感染病科）
参考文献：
[1]Bronowicki JP,Ouzan D,Asselah T,et al.Effect of ribavirin in genotype l patients with hepatitis C responding to pegylated interferon alfa-2a plus ribavirin.Gastroenterology,2006,131:1040-1048.
[2]中华医学会肝病学分会,中华医学会传染病和寄生虫病学分会.丙型肝炎防治指南.中华传染病杂志,2004,22:131-136.
[3]Reddy KR,Shiffman ML,Morgan TR,et al.Impact of ri上一页 [1] [2] [3] 下一页
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