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冠状动脉内超声成像对斑块形态 临床综合征及冠状动脉造影的对比研究

曾勇 朱文玲 黄超联 张德利
金征宇 沈珠军 倪超 姜秀春



  【摘要】 目的 研究血管内超声对冠状动脉内斑块形态的分析,以及斑块形态与患者临床表现的关系。方法 对42例冠心病患者行冠状动脉造影及冠状动脉内超声成像检查(ICUS),定性分析斑块形态和性质,并与冠状动脉造影对比。患者根据临床特征分为不稳定型心绞痛组(A组)和稳定型心绞痛组(B组)。结果 冠状动脉造影发现,冠状动脉狭窄程度两组比较无显著性差异,而对比两组超声斑块形态和性质发现A组病变以软斑块多见(A组66%,B组31%,P<0.05),B组则以纤维斑块更常见(B组54%,A组17%,P<0.05)。结论 ICUS对病变形态和性质的分类与临床综合征关系更密切。
  【关键词】 心绞痛  冠状动脉内超声成像术

Intracoronary ultrasound imaging correlation of plaque morphology with clinical syndrome and angiographyZeng Yong, Zhu Wenling, Huang Chaolian, et al. Department of Cardiology, Peking Union Medical College Hospital, Beijing 100730
  【Abstract】 Objective To establish the relationship between ultrasound derived atheroma morphology and angiography with clinical syndrome. Methods Forty two patients were examined by intracoronary ultrasound imaging (ICUS) and coronary angiography. Ultrasound images were analyzed for percent plaque areas and classified into four morphologic subtypes (soft, fibrous, calcific, mixed plaque). Ultrasound data were compared with angiographic feature and clinical angina pattern.Results Ultrasound lesion morphology well correlated with the clinical angina syndrome. Compared with stable angina, patients with unstable angina had more soft lesions (66% vs 31%, P<0.05), less fibrous lesions (17% vs 54%, P<0.05). But the degree of stenosis shown angiographically revealed no significant difference between patients of stable and unstable angina. Conclusion ICUS can detect early process of atherosclerosis. Ultrasound classification of plaque morphology is closely correlated with clinical angina sysdrome.
  【Key words】 angina  intracoronary ultrasound angiography

   在过去的几十年里,冠状动脉造影被认为是诊断冠心病的金标准,但是它的局限性亦逐渐为人们所认识。冠状动脉内超声成像由于能够准确提供血管管腔及管壁的信息,并能够对粥样病变的性质做出准确的判断,在冠心病的诊断及治疗中起着重要的作用。本文对我院42例冠状动脉内超声(ICUS)检查进行分析,并对比冠状动脉造影以明确ICUS检查在冠心病诊断和治疗中的作用。


对象和方法


  研究对象: 42例冠状动脉造影的患者包括急性心肌梗塞17例,因胸痛,经心电图、平板运动

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