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获得性血友病A动物模型的建立及应用评价 |
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【摘要】 目的 建立获得性血友病A兔模型并评价其意义。方法 输注获得性血友病A患者血浆入健康新西兰兔体内，测定注射血浆前30 min及注射血浆后30 min、60 min、90 min、120 min时间点兔血浆活化部分凝血活酶时间（aPTT），观察获得性血友病A患者体内FⅧ抑制物对兔血浆aPTT值的影响，以等量正常人血浆注入新西兰兔作为对照。结果 输注患者血浆入新西兰兔体内，兔血浆aPTT明显延长，且以时间依赖性方式抑制兔血浆FⅧ:C活性，输注正常人血浆对兔aPTT及BT值无明显影响。结论 采用输注患者血浆入健康新西兰兔体内可成功建立获得性血友病动物模型,为进一步探讨获得性血友病A的新药物治疗，提供了药物试验的动物疾病模型。
【关键词】 获得性血友病A； 动物模型
The Establishment and Evaluation of the Rabbit Animal Model of Acquired Haemophilia A
ZUO Wenli1 ZHANG GuangSen2 LIU GuoWen3
(1. Department of Hematology, Hennan Cancer Province Hospital, Zhengzhou 450052 China;2.Department of Hematology,the Second Xiangya Hospital, Central South Univercity, Changsha, 410011 China;3.Department of Surgery,the Second Xiangya Hospital, Central South Univercity, Changsha , 410011,China)
Abstract: Objective To set up and evaluate the rabbit animal model of acquired haemophilia A.Methods Pateint’s plasma of acquired haemophilia A was infused into rabbits by intravenous injection and blood sample were collected at different timepoint (including preinfusion 30 min、 postinfusion 30 min,60 min,90 min,120 min separately). Then rabbit plasma aPTT values were evaluated, equal volume of normal plasma&nb[1] [2] [3] [4] 下一页
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