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妊娠高血压综合征患者血浆对体外培养的内皮细胞合成血管活性物质的影响 |
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, levels of 6-keto-PGF1α produced by cultured endothelial cells were measured. Results The mean values of 6-keto-PGF1α in matrnal venous plasma were (94.49±25.23) ng/L in preeclamptic group and (248.81±51.99) ng/L in normal pregnant group. Plasma TXB2 values were (104.61±13.12) ng/L in preeclamptic group and (66.26±38.80) ng/L in normal pregnant group. TXB2/6-keto-PGF1α ratios were (1.11±0.03) in preeclamptic group and (0.28±0.02) in normal pregnant group. Maternal plasma values of 6-keto-PGF1α were lower in peeclamptic group than those of normal pregnant group (P<0.01). On the other hand, plasma TXB2 values were higher in preeclamptic group than in normal pregnant group (P<0.01). TXB2/6-keto-PGF1α ratios, however, were significantly different between the two groups (P<0.01). The values of 6-keto-PGF1α produced by cultrued endothelial cells exposed to 2% plasma were (1 363.00±99.16) ng/L in preeclamptic group and (819.49±96.62) ng/L in normal pregnant group (P<0.01). Conclusions PGI2 and TXA2 may play an important role in preeclampsia. Plasma from women with preeclampsia could stimulate the production of prostacyclin in cultured endothelial cells in vitro.
【Key words】 Pregnancy Complications, cardiorascular; Hypertension; Pre-eclampsia; Epoprostenol; Thromboxanes; Endothelium
妊娠高血压综合征（妊高征）是常见的严重危害母婴健康的妊娠并发症，它的病理生理学特征是血管反应性增加，凝血机理激活，这些都与内皮细胞功能有关。妊高征内皮细胞损伤是胎盘产生的物质释放入孕妇血循环引起的。这一说法可通过研究妊高征患者的血清或血浆对体外培养的内皮细胞的影响来证实。本研究是在体外培养的牛肺动脉内皮细胞中加入先兆子痫患者或正常晚期妊娠妇女的血浆，共同孵育24 h后，测定内皮细胞释放的前列环素（PGI2）和血栓素(TXA2)的水平，判断先兆子痫患者血浆中是否存在某些影响内皮细胞合成血管活性物质的因子。
资料与方法
一、研究对象
选择1998年9月～1999年3月在第四军医大学唐都医院产科住院患者，其中先兆子痫患者（先兆子痫组）20例，妊高征的诊断标准参照全国统编教材《妇产科学》第4版。正常晚期妊娠妇女（正常晚孕组）15例， 为同期住院健康孕妇。两组既往均无高血压、心脏病、糖尿病及肝肾病史。先兆子痫组平均年龄为(26.95±9.63)岁， 平均孕周为(37.25±2.72)周；正常晚孕组平均年龄为(26.67±8.09)岁，平均孕周为(37.93±3.07)周，两组孕妇年龄、 孕周比较，差异均无显著性（P>上一页 [1] [2] [3] 下一页
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