【摘要】目的：探讨间苯三酚(spasfon)在引产中的可行性及安全性。方法:对因胎膜早破6 h以上、未临产、无引产禁忌症的足月妊娠初产妇120例，随机分为两组，两组均静脉滴注0.5%的催产素以调整宫缩，spasfon组在有中等以上规律宫缩时静脉推注spasfon 80 mg;对照组单纯应用催产素静脉滴注。结果:spasfon组引产成功率明显高于对照组且能明显缩短产程。结论:spasfon用于胎膜早破引产效果显著，且安全、可靠。
【关键词】 间苯三酚 引产 胎膜早破
Application of spasfon in the induced labor with premature rupture of membranes
LAN Qiuhong
(Pingyuan People s Hospital in Guangdong Provincial Pingyuan 514600,China)
[ABSTRACT] Objective: To determine the feasibility and safety of spasfon in the induced labor with premature rupture of membranes. Methods: One hundred twenty primary full-term pregnant women, without onset of labor and no contraindication for induced labor, undergoing induced labor due to premature rupture of membranes for more than 6 h, were divided randomly into trial group(n=60) and control group(n=60). Pregnant women in trial group were treated with 0.5% oxytocin intravenously firstly, spasfon 80mg was intravenous injected with bolus after moderate uterine contraction; pregnant women in control group were treated with 0.5% oxytocin intravenous titration alone. Results: The success rate of induced labor in trial group was strikingly higher than that in control group; labor stage in trial group was shorter than that in the control group. Conclusion: Spasfon for induced labor with premature rupture of membranes is effective, safe and reliable.
[KEY WORDS] Spasfon; Induced labor; Premature rupture of membranes
近年来，应用间苯三酚(spasfon)配合催产素用于胎膜早破引产，对其有效性及安全性进行了一系列研究，取得了一定的效果，现报道如下。
1 资料与方法
1.1 一般资料
选择足月妊娠、单胎头位、胎膜破裂达6 h、羊水清的未临产初产妇120例为研究对象，随机分为观察组和对照组各60例，两组的年龄、身高、体重、胎儿大小、胎方位和宫颈评分等因素基本相似，无妊娠合并症，无头盆不称及骨盆异常，经统计学处理无显著性差异(P>0.05)，具有可比性。
1.2 方法
两组产妇均以催产素2.5 U溶于5%的葡萄糖注射液500 mL中静脉滴注，由专人守护，根据宫缩情况调节催产素滴注速度，用产程图严密观察产程进展，观察组在有中等以上规律宫缩时采用间苯三酚80 mg静脉缓慢推注。观察两组剖宫产率，第1产程、第2产程、第3产程时间，终止妊娠时羊水情况，新生儿评分及产后出血情况。
1.3 统计学处理
所获数据采用SPSS10.0统计软件进行统计分析，两样本均数比较用t检验
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