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白癜风人群雌激素受体基因多态性与临床资料相关性分析 |
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【关键词】 雌激素受体
Association between estrogen receptor gene polymorphism in vitiligo patients and their clinical data
【Abstract】 AIM: To study the association between estrogen receptorα（ERα）gene polymorphism in vitiligo patients and their clinical data． METHODS: Polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP) was used to study the ERα intron 1 Pvu II C/T (rs2234693) polymorphisms in 466 patients with vitiligo. Genotypes were determined and allele frequencies were compared to find their relationship with their clinical data. RESULTS: The genotype and allele frequency distributions were not significantly different among vitiligo patients with different subtypes, sex, onset age, with/without other autoimmune diseases and family history (P>0.05), while P values were in the range of 0.081-0.364 between segmental and two generalized type vitiligo patients (segmental vs universal, P=0.100; segmental vs common, P=0.081). And P values were near 0.05 when the C/T genotype frequency was compared between onset age of lower than 12 years old and of 12-20 years old (P=0.085); P values were also low in comparisons of genotype (P=0.195) and allele frequencies (P=0.165) between the male and the female patients. CONCLUSION: When the genotype and allele frequencies of the ERα intron 1 C/T polymorphism were compared among vitiligo patients with different subtypes, sex, onset age, with/without other autoimmune diseases and family history, no significant difference was observed. However, a tendency of significant differences was observed in comparisons of female and male vitiligo patients, segmental and generalized types, and different onset age (<12 years old vs 12-20 years old). ERα gene may be a possible risk factor especially for the female, generalized type or children vitiligo patients.
【Keywords】 estrogen receptoralpha; polymorphism, genetic; vitiligo; clinical data
【摘要】 目的： 探讨白癜风人群雌激素受体α（estrogen[1] [2] [3] [4] 下一页
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