【摘要】 目的 观察干扰素、酚妥拉明联合治疗毛细支气管炎的临床疗效。方法 将120例毛细支气管炎患儿随机分成观察组和对照组，每组60例。对照组予以抗感染、解痉平喘、吸氧、镇静等一般综合治疗，观察组在此基础上应用干扰素10万u·kg-1·d-1(最大剂量为100万u)，肌肉注射;酚妥拉明0.1～0.3 mg·kg-1·d-1，静脉滴注，均每日1次，联合用药3 d。结果 观察组喘憋消失时间、呼吸困难缓解时间、肺部啰音消失时间及住院时间均明显短于对照组(P<0.05);观察组3例出现轻微鼻塞，其他患者未见明显不良反应。结论 干扰素、酚妥拉明联合治疗毛细支气管炎疗效确切。
【关键词】 干扰素;酚妥拉明;毛细支气管炎
Curative effect of interferon and phentolamine on children with bronchiolitis
YAN Hongmin
(Department of Pediatry，the Hospital of Maternal and Child Health of Yuzhou City,Yuzhou 641400,China)
Abstract: Objective To observe the curative effect of interferon and phentolamine on children with bronchiolitis.Methods One hundred and twenty children with bronchiolitis were randomly divided into two groups.Sixty cases in every group.The common combined therapy of antiinfection,spasmolysis and mitigation was carried out in control group,based on this,children in observation group were treated with interferon 10万u·kg-1·d-1(the maximum dose was 100万u) by intramuscular injection,and phentolamine 0.1-0.3 mg·kg-1·d-1 by intravenously guttae,once a day,for three days.Results The extinction time of gasp,anhelation,pneumonic rattle and the length of stay(LOS) were shorter obviously in observation group than these in control group(P<0.05).There were three cases with slight nasal obstruction in observation group,there was no other adverse effect in two groups.Conclusion The curative effect of interferon and phentolamine on children with bronchiolitis was preonunced.
Key words: interferon;phentolamine;bronchiolitis
毛细支气管炎是主要由呼吸道合胞病毒(respiratory syncytial virus，RSV)引起的急性毛细支气管炎症，主要临床表现均以急性起病、阵发性喘憋、明显呼气性呼吸困难和哮鸣音为主要特征，急性期往往病情较重，病程进展快，如不及时处理可危及生命[12]。禹州市妇幼保健院儿科2000年1月至2008年1月应用干扰素联合酚妥拉明治疗毛细支气管炎60例，效果良好，现报道如下。
1 资料与方法
1.1 一般资料
120例毛细支气管炎患儿均符合《实用儿科学》毛细支气管炎的诊断标准[3]。并排除了合并先天性心脏病、免疫缺陷病、遗传病、营养不良等病例。每例患儿均有咳嗽、频发喘憋、鼻煽、口唇发绀、呼吸心率增快、面色苍白的表现;其中心力衰竭17例，呼吸衰竭9例，腹胀15例，酸中毒6例。将120例患儿随机
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