葛根素对急性拟除虫菊酯杀虫药中毒心血管系统的保护作用

　　【摘要】目的 观察葛根素注射液对急性拟除虫菊酯杀虫药中毒性心肌损害的辅助治疗作用。方法 将89例拟除虫菊酯杀虫药中毒性心肌损害患者随机分为治疗组45例，对照组44例。两组均予洗胃、补液、利尿、控制抽搐及对症支持等常规治疗, 治疗组加用葛根素注射液0.3～0.6 g, 每日1～2次，连用7～10 d。对比分析两组患者的心电图、心肌酶谱变化及平均住院天数。结果 心电图、心肌酶谱及平均住院天数，治疗组均优于对照组(P<0.05或P<0.01)。结论 葛根素注射液对拟除虫菊酯杀虫药中毒性心肌损害有明显保护作用。

　　【关键词】 急性拟除虫菊酯杀虫药中毒 心肌损害 葛根素注射液

　　The protection of kakkonein on cardiovascular toxicity with acute pyrethroid insecticide poisoning

　　Wang Bangben, Yin Sixiang, Wang Liuqing

　　Department of Medicine, Health Center in Zongyang Town Zongyang County,Zongyang 246700,China

　　[Abstract] Objective To study the antagonistic effect of kakkonein injection on cardiovascular toxicity in patients with acute pyrethroid insecticide poisoning (APIP).Methods According to the sequence of patients that admitted in hospital, the 89 patients with APIP were randomly divided into two groups the routine therapy treated group and kakkonein injection treated group. The routine therapy treated group was given emergency treatment as gastric lavage, catharsis, fluid infusion, respiration supporting and so on. Based on routine emergency treatment, the kakkonein injection treated group was treated by kakkonein injection. Electrocardiogram (ECG), myocardial enzyme spectrum and average hospital day were observated, then compared with each other.Results ECG, myocardial enzyme spectrum and average hospital day in kakkonein injection treated group were significantly well than those in the routine therapy treated group.Conclusion It is suggested that kakkonein injection has the protective effect on cardiovascular toxicity in patients with APIP.

　　[Key words] Acute pyrethroid insecticide poisoning;Cardiovascular toxicity;Kakkonein injection

　　拟除虫菊酯杀虫药 (pyrethroidnsecticide) 是一种应用广泛的广谱高效杀虫剂。拟除虫菊酯杀虫药中毒常引起各种脏器损害，其中以心肌损害最为常见。本文收集2000年9月至2008年9月间急性溴氰菊酯等中毒者89例进行分析,在常规救治的基础上,使用葛根素注射液治疗, 动态观察其对心电图(ECG)及心肌酶及患者平均住院天数的影响, 并与对照组相比较, 疗效显著，现报告如下。

　　1 资料与方法

　　1.1 病例纳入标准

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