Gwe治疗对慢性肝炎患者血清补体溶解免疫复合物能力的影响

焦顺昌　李求是　钟大光　周严恒　

　　中国图书分类号　R512.620.5　R392
　　摘　要　目的：探讨Gwe口服液对慢性迁延型肝炎患者血清补体溶解免疫复合物能力(CMSC)的影响。方法：以健康献血员为对照，采用改良的天野氏比色法，测定18例慢性迁延型肝炎患者服用Gwe前后1个月左右的CMSC。结果：患者的CMSC下降为84.3%(P=0.02)，经Gwe治疗后恢复正常。血清C3含量与其CMSC水平呈显著正相关(r=0.922,P＜0.01)，血清CMSC与C4之间无显著相关性。结论：Gwe治疗后CMSC活性显著升高，有利于减少免疫复合物的沉积，阻断慢性肝炎的病理进程。
　　关键词　慢性迁延型肝炎　Gwe　血清溶解免疫复合物能力

Effects of Gwe on the serum complement mediated immune complex solubilizing capacity in chronic persistent hepatitis patients

JIAO Shun-Chang,LI Qiu-Shi,ZHONG Da-Guang et al.
General Hospital of PLA,Beijing 100853

　　Abstract Objective：To discuss the effect of Gwe on the serum complement mediated immune complex solubilizing capacity in chronic persistent hepatitis patients.Methods:Serum complement mediated immune complex solubilizing (CMSC)was measured in 18 chronic persistent hepatitis (CPH) patients and in 10 normal individuals.Results:It was found that the level of serum CMSC in the CPH patients was significantly lower than that in normal individuals(P=0.02)，and was significantly increased after treating with Gwe for a month.There was a positive relationship between the CMSC and serum C3 level in 18 patients,while the relationship of the CMSC with serum C4 was not found.Conclusion:The increased activity of CMSC after Gwe treatment is helpful to clean the deposited immune complex,and to discontinue the progress of chronic hepatitis.
Key words Chronic persistent hepatitis Gwe Serum complement mediated immune complex solubilizing

　　慢性乙型肝炎是一种免疫复合物性疾病，抗体以及少量自身抗体形成的免疫复合物在血清中存在，并沉积于肝、肾、关节、心脏等组织器官，导致肝组织损伤及一系列肝外表现［1］。血清补体可促进免疫复合物被单核细胞清除［2］，是抗御免疫复合物疾病的重要环节之一。Gwe口服液是一种中草药制剂，具有促进慢性乙型肝炎患者血清HBsAg阴转、肝功恢复等一系列良好的临床疗效,并可使慢性乙肝患者循环免疫复合物显著下降［3］。为了进一步探索其循环免疫复合物下降的机制，我们测定了18例服用Gwe口服液前后一个月左右的患者血清溶解免疫复合物的活性，为临床治疗提供理论依据。

1　材料与方法
1.1　试剂
1.1.1　可溶性HRP-抗HRP 复合物及底物　购于军事医学科学院微生物及流行病学研究所，效价为1∶3 000。
1.1.2　聚乙二醇(PEG6000)　上海生化所产品。
1.1.3　血清补体C3、C4测定试剂盒　购于海军总医院。
1.2　研究对象

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