|
干扰素α与阿德福韦酯不同联合方法治疗HBeAg阳性慢性乙型肝炎的疗效 |
| |
l of Hebei Medical University,Shijiazhuang 050051,China） CHE Hong-hao（Department of Infectious Diseases,Third Affiliated Hospital of Hebei Medical University,Shijiazhuang 050051,China） JI Ru（Department of Infectious Diseases,Third Affiliated Hospital of Hebei Medical University,Shijiazhuang 050051,China） YANG Bo（Department of Infectious Diseases,Third Affiliated Hospital of Hebei Medical University,Shijiazhuang 050051,China）
Abstract：Objective To investigate the efficacy of interferon α(IFNα)and adefovir dipivoxil (ADV)combination therapy in HBeAg positive chronic hepatitis B(CHB)patients and to explore the optimized strategy for individualized treatment.Methods A total of 156 HBeAg positive CHB patients were enrolled in the study from January 2005 to June 2009 in the Third Affiliated Hospital of Hebei Medical University.Fifty-six CHB patients with hepatitis B virus(HBV)DNA≥1 X 107copy/mLand/or liver fibrosis stage≥S3,or previous monotherapy failure(relapse)were treated with initial IFNα and ADV combination therapy.Fifty-two patients who didn't meet any of the above baseline characteristics received initial IFNα monotherapy.The remaining 48 patients treated with IFNα monotherapy for full treatment duration were considered as control.At week 24 of treatment,the treatment regimens were adjusted according to quantitative changes of HBV DNA,HBeAg and HBsAg:16 patients who achieved early response in group of initial IFNα and ADV combination therapy subsequently received IFNα monotherapy,the other patients in group of initial combination therapy together with patients who did not achieved early response in group of initial IFNα monotherapy subsequently received IFNα and ADV combination treatment.The HBV DNA levels,HBeAg and HBsAg titers were detected at the end of 48 weeks of treatment to determine the treatment duration.The treatment efficacy,safety,drug resistance and relapse rates were finally 上一页 [1] [2] [3] 下一页
上一个医学论文： CD150在成人乙型肝炎疫苗无应答者体外外周血单个核细胞中的表达
下一个医学论文： 利巴韦林累积剂量对基因1型慢性丙型肝炎患者病毒学应答率的影响
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 内科论文 >> 正文