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肺移植供体的选择和处理

、特别是前列环素(血管扩张剂、抗血小板物质和细胞保护剂)在防止氧自由基形成的研究中越来越受到重视。

  5.异种移植将解决供体短缺的问题,在其他大器官移植中也曾试用过,但异种肺移植尚无临床经验,这将依赖于免疫抑制方面的进一步发展。参考文献

  1Harjula A, Baldwin JC, Starnes VA, et al. Proper donor selection for heart-lung transplantation. J Thorac Cardiovasc Surg, 1987, 94:874 ~880.

  2 Griffith BP, Zenati M. The pulmonary donor. Clin Chest Med, 1990,11:217 ~226.

  3 Winton TL. Lung transplantation:donor selection.Semin Thorac Cardiovasc Surg, 1992, 4:79~82.

  4 Lloyd KS, Barnyard P, Holland VA, et al. Pulmonary function after heart- lung transplantation using larger donor organs. Am Rev Respir Dis, 1990, 142:102 6~1029.

  5 Sanfillipo F, Vaughn WK, Specs EK, et al. Benefits of HLA-A and HLA-B ma tching on graft and patient outcome after cadaveric-donor renal transplantation. N Eng1 J Med, 1984, 311:358~364.

  6 Wreghitt TG, Hakim M, Gray JJ, et al. Cytomegalovirus infections in hear t and heart and lung transplant recipients. J Clin Pathol, 1988,41:660~667.

  7 Bailey TC, Trulock EP, Ettinger NA, et al. Failure of prophylactic gancy clovir to prevent cytomeg-alovirus disease in re cipients of lung transplants. J Infect Dis, 1992;165:548~552.

  8 Ho M, Suwansinikul S, Dowling JN, et al. The transplanted kidney as a s ource of cytomegalovirus infection. N Eng1 J Med, 1975,293:1109~1112.

  9 Date H, Lima 0, Matsumura A, et al. In a canine model, lung preservation at 10℃ is superior to that at 4℃.J Thorac Cardiovasc Surg, 1992, 103:773~780 .

  10 Mayer E, Puskas JD, Cardoso PFG, et al. Reliable eighteen-hour lung pre servation at 4℃and 10℃ by pulmonary artery flush after high-dose prostaglandin ED administration. J Thorac Cardiovasc Surg, 1992,103:1136~1142.

  11 Haverich A, Aziz S, Scott WC, et al. Improved lung preservation using E uro-Collins solution for flush perfusion. J Thorac Cardiovasc Surg, 1986,34:368 ~376.

  12 Puskas JD, Hirai T, Christie N, et al. Reliable thirty-hour lung preser vation by donor l

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