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原发性肾病综合征患者血栓前状态的研究 |
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【摘要】 目的 探讨原发性肾病综合征患者血栓前状态指标：血浆血管性血友病因子（vWF）、D二聚体、纤维蛋白原、抗凝血酶水平的变化及其临床意义。方法 用法国产STAR全自动血凝检测仪检测原发性肾病综合征组和正常对照组血浆vWF、D二聚体、纤维蛋白原、抗凝血酶水平。结果 原发性肾病综合征患者血浆vWF、D二聚体、纤维蛋白原水平显著高于对照组（P﹤0.01），而抗凝血酶Ⅲ水平低于对照组（P﹤0.05）。结论 血浆vWF、D二聚体、纤维蛋白原水平升高与原发性肾病综合征患者血液高凝状态及血栓形成有一定关系。
【关键词】 肾病综合征； 血管性血友病因子； D二聚体； 纤维蛋白原； 抗凝血酶
The Study of Prethrombotic State in Patients with Primary Nephrotic Syndrome
ZHANG Yaqing, LI Xiaodong
(Tangshan Worker’s Hospital, Tangshan 063000, China)
Abstract: Objective To study the changes and clinical significance of plasma von willebrand factor(vWF), Ddimer, fibrinogen(Fbg) and antithrombase(AT) in patients with primary nephrotic syndrome.Methods STAR instrument made in France was used to detect the plasma levels of vWF, Ddimer, Fbg and AT.Results The levels of plasma vWF, Ddimer, Fbg in patients with primary nephrotic syndrome were significantly higher than that in the control group（P﹤0.01）, while the level of AT was lower than that in the control group（P﹤0.05）.Conclusion The increased levels of plasma vWF, Ddimer, Fbg maybe have relations with hypercoagulations state and thrombosis of patients with primary nephrotic syndro[1] [2] [3] [4] 下一页
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