【摘要】 目的 探讨体外受精―胚胎移植治疗周期中注射绒毛膜促性腺激素(HCG)日血清促卵泡生成素(FSH)、促黄体生成素(LH)、泌乳素(PRL)、雌激素(E2)、孕激素(P)水平与卵子成熟、受精、卵裂、胚胎质量及妊娠的关系。方法 2003年8～12月在我院接受卵泡浆内单精子注射(ICSI)治疗的48例不孕妇女，注射HCG前采用磁性分离酶免疫法测定血清FSH、LH、PRL、E2、P的水平，观察其与卵子成熟、受精、卵裂、胚胎质量及妊娠的关系。结果 获卵数与E2的水平呈正相关;卵子的成熟率与LH呈负相关;卵裂率与E2、P呈正相关;将卵裂率分为高(≥90%)、中(80%～90%)、低(<80%)三组时，卵裂率高组E2、P的水平显著高于低组，卵裂率高组与中组E2、P的水平差异无显著性，中组与低组E2、P的水平差异无显著性;卵子的成熟率与血清FSH、PRL、E2、P无关;受精率与血清FSH、LH、PRL、E2、P均无关;卵裂率与FSH、LH、PRL、P无关;优胚率与血清FSH、PRL、E2、P无关;注射HCG日妊娠组血清FSH、LH、PRL、E2、P的水平与未妊娠组相似。结论 在体外受精―胚胎移植超排卵治疗周期中，注射HCG日E2的水平能够反映卵巢对促排卵药物反应的高低，LH水平升高能够导致卵子的成熟率下降，卵裂率高的患者注射HCG日血清E2、P高于卵裂率低的患者，血清FSH、PRL、E2、P的水平不影响卵子的成熟，血清FSH、LH、PRL、E2、P的水平与受精率、优胚率、妊娠率无关。
【关键词】 体外受精―胚胎移植;血清性激素;受精率;卵裂率;妊娠
Relationship between serum sex hormone levels and development of human embryos and pregnancy during in vitro fertilization and embryo transfer
REN Haiqin,WANG Wenge,LI Wei,et al.
Reproductive Center,Jinghua Hospital,Shenyang Dongfang Medical Group,Shenyang 110005,China
【Abstract】 Objective To study the relationship between serum sex hormone levels on the day of human chorionic gonadotropin (HCG) injection and oocyte maturation,fertilization,cleavage and embryos quality and pregnancy during in vitro fertilization and embryo transfer.Methods 48 women underwent intracytoplasmic sperm injection (ICSIET) mostly because of male factor under controlled hyperstimulation with gonadotropin releasing hormone antagonists/follicle stimulating hormone/human menopausal gonadotropin/human chorionic gonadotropin (GnRHa/FSH/HMG/HCG).FSH，LH，PRL，E2 and P in serum were measured by MEIA technology on the day of HCG injection.Results The numbers of obtained oocytes was positive related with E2 level (r=0.797,P<0.01);the oocyte maturation rate was negative related with LH (r=0.571,P<0.01);the oocyte cleavage rate was positive related with E2 and P level (r=0.346,P<0.05;r=0.314,P<0.05);E2 and P level in oocyte cleavage rate≥90% group was higher than
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