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花椒油素对肺血栓及6 |
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金云海 单春文 程远远
摘要：以胶原和肾上腺素混合液给小鼠，制造肺血栓模型，用放免法测定6-酮-前列腺素F1α(6-keto-PGF1α)和血栓素B2(TXB2)含量。结果表明，花椒油素(Xanthoxylin，XT)1.0mg/kg，2.0mg/kg，4.0mg/kg和8.0mg/kg使小鼠的存活率增加28.6%～71.2%；使6-keto-PGF1α的产量提高56.3%～210.8%，使TXB2的产量降低21.6%～56.8%。6-keto-TGF1α与TXB2的比值明显提高，对照组为1.15，药物组为2.29，3.13，5.53，8.26。体外实验证明，XT0.037μmol/L，0.185μmol/L，0.924μmol/L，9.240μmol/L显著地抑制血小板聚集和TXB2产生，前者的抑制率为22.7%～55.3%，后者为20.5%～50.7%；但同时增加6-keto-PGF1α的产量，提高率为27.3%～47.0%。6-keto-PGF1α与TXB2比值：对照组为1.23，药物组为2.07，2.44，3.28，3.85。
关键词：花椒油素/药理学；6-酮-前列腺素F1α/药物作用；血栓素B2/药物作用；血小板聚集/药物作用
中图分类号：R285.5 文献标识码：A
文章编号：1003-9783(2000)02-0088-03
Effects of Xanthoxylin on the Amount of 6-keto-prostaglandin Fla and
Thromboxane B2 in Mice with Pulmonary Thromboembolism
Jin Yunhai
（Department of Pharmacology, First Military Medical University,Guangzhou 510515;）
Shan Chunwen
（Department of Pharmacology, First Military Medical University,Guangzhou 510515;）
Cheng Yuanyuan
（Department of Pharmacy,First Affiliated Hospital of Medical College of Jinan University,Guangzhou 510630）
Abstract：Model mice with pulmonary thromboembolism were established by administration of mixture of collagen and adrenaline.Radioimmunoassay was used to detect the serum level of 6-keto-prostaglandinFla(6-keto-PGFla) and thromboxane B2(TXB2).Results showed that xanthoxylin being at the concentration of 1.0,2.0,4.0,8.0mg/kg,the survival rate of mice was increased by 28.6%～71.2%,the amount of 6-keto-PGFla by 56.3%～210.8%,and the amount of TXB2 by 21.6%～56.8%.The ratio of 6-keto-PGFla and TXB2 was enhanced markedly,being 1.15 in the control group, and 2.29,3.13,5.53 and 8.26 in the medication groups respectively.In vitro,xanthoxylin in the dosages of 0.037,0.185,0.924,9.240 μmol/L significantly inhibited the aggregation of platelet and the production of TXB2,with the inhibition rate of 22.7%～55.3%[1] [2] 下一页
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