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罗库溴铵量效关系两种测定方法的比较


陈锡明 杭燕南 孙大金

摘要 目的:分别选用单次法和二次累积法测定罗库溴铵的剂量和效应的关系。方法:34例,ASAⅠ~Ⅱ级,年龄23~65岁,施行择期腹部或颅脑手术的患者,分为单次法组和累积法组。单次法24例,分为4个亚组,分别接受罗库溴铵150、200、250和300μg/kg。累积法10例,分为2个亚组,首次剂量分别接受罗库溴铵150或200μg/kg,阻滞达最大时追加第二次剂量,使阻滞达90%左右。采用对数剂量和概率单位转换和直线回归计算量效应曲线。结果:单次法求得的ED50和ED95分别193.6±69.1和367.2±72.75μg/kg,累积法分别为213.0±55.1和418.5±61.7μg/kg。两种方法求得的ED50、ED95、曲线斜率和截距均无显著性差异。结论:用累积法测定罗库溴铵的量效应关系,可以省时、省工,而结果同样可靠。
关键词 罗库溴铵 累积法 剂量效应关系,药物

Comparison of cumulative and single dose techniques for determining dose-response relationship of rocuronium Chen Ximing,Hang Yannan,Sun Dajin.Department of Anesthesia,RenJi Hospital,Shanghai Second Medical University,Shanghai 200001
Abstract Objective:To compare cumulative dose technique with single dose technique for determining dose-response relationship of rocuronium during balanced anesthesia.Method:Thirty-four ASA grade Ⅰ-Ⅱ patients,aged 23-65 years,undergoing elective surgery,were randomly allocated to single dose group(n=24) or cumulative dose group(n=10).Single dose group was further divided into 4 subgroups receiving 150,200,250 or 300μg/kg of rocuronium respectively.In cumulative dose group,the initial dose of 150 or 200 μg/kg rocuronium was followed by a second dose determined individually to produce about 90% neuromuscular block.The ulnar nerve was stimulated at the wrist to measure the accelography of thumb adduction.The relationship between probit-transformed depression of first twitch height of TOF and the logarithm dose of rocuronium was analysed using linear regression.Result:ED50 and ED95 of rocuronium were 193.6±69.1 and 367.2±72.7μg/kg respectively in single dose group,and 213.0±55.1 and 418.5±61.7μg/kg respectively in cumulative dose group.No statistically significant differences were found in the slope,intercept,ED50 and ED95 values between two groups.Conclusion:The two-dose cumulative technique can be used as

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