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京、津、沪、渝四城市肺癌危险因素病例对照研究 |
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俞敏 饶克勤 陈育德
【摘要】 目的 分析肺癌危险因素，探讨监测指标。方法 利用《常见恶性肿瘤发病、死亡及危险因素监测方法研究》课题第1次现场调查中京、津、沪、渝四市城区病例对照调查资料，运用多因素条件logistic回归分析方法。结果 在调整年龄、受教育程度、人均月收入和控制其他因素作用的基础上，吸烟（OR=3.46）、体质指数小（OR=1.18）、长期精神压抑（OR=2.64）、情绪调节能力差（OR=2.71）、既往呼吸系疾病史（OR=2.28）、家族肿瘤史（OR=1.79）、职业接触（OR=1.43）与肺癌的关联有显著性，体育锻炼（OR=0.81）、新鲜蔬菜摄入多（OR=0.75）与肺癌呈负关联,四市肺癌的主要危险因素结果基本一致。结论 吸烟、心理因素、既往呼吸系疾病史、家族肿瘤史是四市肺癌共同的主要危险因素；环境烟雾、食物等有待于进一步研究。
【关键词】 肺肿瘤； 危险因素； 病例对照研究； Logistic模型
A Case-control study of the risk factors of lung cancer in Beijing, Tianjin, Shanghai, Chongqing metropolitan areas
YU Min*, RAO Keqin, CHEN Yude
（Sanitary and Anti-epidemic Station of Zhejiang Province, Hangzhou 310009, China）
【Abstract】 Objective To analysis the risk factors of lung cancer and determine the surveillance index in urban areas in four metropolises in China. Methods The paper used the data from the in-person interviews of National Research on Malignant Tumor Morbidity, Mortality and Surveillance Methods in 1996. We carried out a 1∶1 matched case-control study based on population involving 1 312 cases and 1 312 neighborhood controls aged 35-74 from Beijing, Tianjin, Shanghai, Chongqing urban areas. The relationships between risk factors and lung cancer were analyzed by conditional univariant and multivariate logistic regression on the computer package, STATA. Results Cigarette smoking, lower body mass index, longtime depressed mood, lower capability of emotion regulation, previous respiratory diseases, family history of cancer in first-degree relatives significantly increased the risk of lung cancer after adjusted by age, education, family average income and other risk factors. The odds ratios of these risk factors were 3.46 (95%CI 2.70-4.45), 1.18 (95%CI 1.22-1.40), 2.64(95%CI 1.95-3.57), 2.71(95%CI 2.02-3.65), 2.28(95%CI 1.81-2.88), 1.79(95%CI 1.38-2.32), respectively. The odds ratio associated with the highest quartile of fresh vegetables consumption compare[1] [2] [3] 下一页
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