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深圳市居民糖尿病危险因子与Ⅱ型糖尿病发病关系的分析

更新时间:2012-04-19 12:30:45  
刘尊永 程锦泉 彭吉 周华 罗炳锐 池洪珊

  【摘要】 目的 分析深圳地区居民糖尿病危险因子与Ⅱ型糖尿病发病的关系。方法 采用WHO诊断标准,随机抽样8 182人,进行问卷调查、体格检查、血液生化指标测定,用logistic多元回归分析糖尿病危险因子。结果 血清总胆固醇高于正常值范围人群的Ⅱ型糖尿病患病率为12.46%,是正常人群的4.9倍。甘油三酯高于正常值范围人群的Ⅱ型糖尿病患病率为12.60%,是正常人群的5.7倍。高密度脂蛋白低于正常值范围人群的Ⅱ型糖尿病患病率为6.59%,比正常者升高68.7%;而高密度脂蛋白值高于正常值范围人群的Ⅱ型糖尿病患病率仅为2.17%,比正常者降低44.6%。体块指数≥25人群的Ⅱ型糖尿病患病率达8.06%,是体块指数<25人群的2.6倍。腰/臀比值≥1.0的人群Ⅱ型糖尿病患病率高达19.89%,是<1.0人群的5.1倍。高血压患者Ⅱ型糖尿病患病率高达12.48%,是非高血压者的3.8倍。Ⅱ型糖尿病患病率随年龄的增长呈上升趋势,尤以40岁以后人群更为明显。有糖尿病家族史者、分娩巨大婴儿(≥4 kg)史的妇女,Ⅱ型糖尿病患病率明显增加。随着吸烟和/或饮酒量的增加以及年限的延长,Ⅱ型糖尿病患病率明显升高。结论 血清总胆固醇、甘油三酯与血糖呈正相关,高密度脂蛋白胆固醇与血糖呈负相关。总胆固醇、甘油三酯、高密度脂蛋白胆固醇、家族遗传史、肥胖、高血压、巨大婴儿生育史及年龄为Ⅱ型糖尿病主要危险因子。
  【关键词】 糖尿病,非胰岛素依赖型; 危险因素; 胆固醇; 甘油三酯类; 脂蛋白类,HDL

Risk factors of type 2 diabetes in Shenzhen

LIU Zunyong*, CHENG Jinquan, PENG Ji
(Diabetes Research Center, Chinese Academy of Preventive Medicine, Beijing 100050, China)

  【Abstract】 Objective The study was designed to investigate the risk factors of Type 2 diabetes in the new city Shenzhen. Methods A representative sample of 8 182 adults aged over 20 to 75 years old were randomly selected in the residents of Shenzhen, China in 1997. Type 2 diabetes was diagnosed according to the WHO criteria. Questionnaire survey, anthropometric measurement and blood analysis were carried out, and logistic regression analysis was used to study the risk factors. Results The results showed that the prevalence of type 2 diabetes in subjects with high total cholesterol were 4.9 times of those with lower TC value. Subjects with high triglyceride had a prevalence 5.7 times of those who had lower TG. Those HDL-ch had a prevalence 68.7% higher than those with normal HDL-ch value; on the other hand, those HDL-ch >1.91 mmol/L were 44.6% lower in the prevalence than those with normal HDL-ch. The prevalence of type 2 diabetes in subjects with BMI ≥25 were 2.6 times of those with BMI <25. Subject with hypertension (≥140/90 mm Hg) h

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