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两种剂量重组干扰素 |
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姚光弼 计焱焱 张利民 徐道振 高健
陆志檬 邬祥惠 张清波 胡德昌
【摘要】 目的 比较两种剂量的重组干扰素-α2a(rIFN-α2a)对慢性丙型肝炎的疗效。方法 68例经血清学和肝组织学证实的慢性丙型肝炎病人，随机分成两组，其中63例完成全疗程，5例中途退出。A组30例，用rIFN-α2a注射，600万单位每周3次，12周，继之为300万单位每周3次，12周。B组33例，IFN-α2a 300万单位每周3次，共24周。结果 治疗结束时，A组的ALT复常率为60.0%，丙型肝炎病毒(HCV)RNA的阴转率为53.3%。B组的ALT复常率和HCV RNA阴转率分别为72.7%和61.3%。停药6个月后，A组的ALT复常率和HCV RNA阴转率分别为56.7%和63.3%；B组分别为69.7%和54.8%。6例病人在治疗过程中出现干扰素中和抗体，4例显效，2例无效。rIFN-α2a的不良反应与文献报告相同，但绝大多数病人能耐受。本组中，1例因疗程中病情加重，1例白细胞明显降低，1例持续发热而中止治疗。结论 两种剂量的疗效差异无显著性(P＞0.05)。HCV基因型和疗效关系不大，肝组织学病变较轻者疗效较好。
【关键词】 肝炎，丙型 干扰素ALFA-2A
Two doses of recombinant interferon alpha 2a in treating chronic hepatitis C: a randomized comparative study Yao Guangbi*, Ji Yanyan, Zhang Limin, et al. *Shanghai Jing An Qu Central Hospital, Shanghai 200040
【Abstract】 Objective To compare the efficacy of a dose of 3MU of recombinant interferon alpha 2a (rIFN-α2a) three times a week for 6 months with a starting dose of 6MU three times a week for 3 months and subsequent reduction to 3MU three times a week for another 3 months. Methods Sixty-eight serologically and histologically proven chronic hepatitis C patients with elevated serum ALT were randomized into two groups. 63 patients completed the full course of treatment. 5 patients were withdrawn from the trial, 2 due to personal reasons and 3 due to aggravation of the disease or leucopenia during treatment. 30 patients received 6MU rIFN-α2a three times a week for 3 months followed by 3MU three times a week for another 3 months (group A). 33 patients received 3MU rIFN-α2a three times a week for 6 months (group B). The sex, age, serum bilirubin, ALT and AST levels were well matched in the two groups. Results At the end of 6th month the complete and partial response rates in group A were 60.0% and 16.7% respectively, the clearance of serum hepatitis C virus (HCV) RNA was 53.3%. In group B, the complete and partial response rates we[1] [2] 下一页
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