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瘦素基因nt 19 A G变异与中国人2型糖尿病脂代谢 体脂含量及分布的关系 |
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张蓉 郑以漫 项坤三 贾伟平 潘晓平 陆俊茜
摘 要：目的 观察瘦素基因5'非翻译区第19位核苷酸(nt+19)A→G变异与中国人2型糖尿病患者脂代谢、体脂含量及分布的关系。方法 351例无亲缘关系中国人(其中糖耐量正常者188例，2型糖尿病163例)用聚合酶链反应-限制性片段长度多态性检测瘦素基因nt+19 A→G变异。结果 在2型糖尿病组中，该基因变异与男性的总胆固醇(TC)水平及低密度脂蛋白-胆固醇水平相关(P值分别为0.0036及0.0022)，与女性的腹部皮下脂肪截面积(SA)相关(P=0.0401)。应用协方差分析作体重指数校正后，无论是2型糖尿病男性或女性亚组中，均可见GG纯合子具有较高的SA(P值分别为0.0255及0.0432)。进一步用Logistic回归分析发现：瘦素基因nt+19 A→G变异与2型糖尿病男性的SA(P=0.0005)、腹部内脏脂肪截面积(VA)(P=0.0286)及TC(P=0.0262)相关，在2型糖尿病女性中与SA(P=0.0002)及VA(P=0.0043)相关。结论 瘦素基因nt+19 A→G变异影响中国人2型糖尿病局部体脂分布，且主要影响腹部皮下脂肪的分布。
关键词：突变；糖尿病，非胰岛素依赖型；瘦素；体脂分布
The association between nt+19 A→G variant of the leptin gene and lipid metabolism, body fat distribution in type 2 diabetic Chinese
ZHANG Rong ZHENG Yiman XIANG Kunsan et al
（Department of Endocrinology and Metabolism,Diabetes Research Laboratory,Medical Genetics Research Laboratory,Shanghai Sixth People's Hospital,Shanghai 200233）
Abstract：Objective To investigate the relationship between nt+19 A→G variant of the leptin (LEP) gene and lipid metabolism, body fat content, body fat distribution in Chinese type 2 DM patients. Methods The genotypes of nt+19 A→G variant in the LEP gene were determined by PCR-RFLP assay in 351 Chinese, including 188 subjects with normal glucose tolerance and 163 type 2 diabetic patients. Results In type 2 diabetic group, an association between nt+19 A→G variant in the LEP gene and serum total cholesterol (TC) level (P=0.0036) and low density lipoprotein-cholesterol level (P=0.0022), was observed in males. While this variant was also associated with abdominal subcutaneous adipose tissue cut area (SA) (P=0.0401) in female. The homozygotes of G-allele in the LEP gene increased SA not only in type 2 diabetic males but also in type 2 diabetic females after correction for body mass index. Furthermore, logistic regression analysis indicated that SA, abdominal visceral adipose tissue cut area (VA) and [1] [2] [3] 下一页
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