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应用硫酸镁治疗胎儿生长迟缓

更新时间:2012-04-21 13:23:15  
谭毅 张文悫 鲁冰 刘春梅

  【摘要】 目的 探讨胎儿生长迟缓(intrauterine growth retardation,IUGR)孕妇的静脉血与新生儿脐静脉血中镁离子含量的变化及其与新生儿体重的关系。方法  将39例IUGR孕妇随机分为治疗1组14例,治疗2组14例,未治疗组11例。治疗1组用10%葡萄糖500 ml+复方丹参液14 ml+低分子右旋糖酐500 ml静脉滴注;治疗2组除有与治疗1组相同的处方外,再加用5%葡萄糖500 ml+25%硫酸镁20 ml静脉滴注,并以同期分娩的12例正常孕妇为对照组。采用全自动生化分析仪,测定4组孕妇的肘静脉血和新生儿脐静脉血中的镁离子含量。结果 治疗1组孕妇静脉血中镁离子含量[(0.69±0.05) mmol/L]和未治疗组[(0.68±0.02) mmol/L]比较,差异无显著性(P>0.05),和治疗2组[(1.06±0.09) mmol/L]比较,差异有显著性(P<0.05),各组新生儿脐血镁离子含量比较,差异有极显著性(P<0.01),对照组和治疗2组、未治疗组和治疗1组比较,差异无显著性(P>0.05),其余各组间比较,差异有极显著性(P<0.01),各组胎盘重量比较,差异有极显著性(P<0.01),各组新生儿体重比较,差异有显著性(P<0.05)。结论 镁缺乏是IUGR发生的原因之一,中晚期孕妇适量补充镁有预防和治疗IUGR的作用。
  【关键词】 硫酸镁; 妊娠并发症; 胎儿生长迟缓

Treatment of Intrauterine Growth Retardation with Magnesium Sulfate

TAN Yi, ZHANG Wenque, LU Bing, et al
(Department of Obstetrics and Gynecology, Second People′s Hospital of Yunnan Province, Kunming 650021, China)

  【Abstract】 Objective To study the relationship between magnesium level in umbilical vein and mother′s peripheral blood with intrauterine growth retardation (IUGR) and fetal weight. Methods 39 pregnant women with IUGR were randomly divided into 3 groups: Group 1 (n=14): The patients were treated with 10% glucose 500 ml + danshen compound 14 ml +low molecular weight dextran 500 ml iv; Group 2 (n=14): in addition to the same treatment as in group 1, 25% magnesium sulfate 20 ml in 5% glucose 500 ml iv was given; Group 3 (n=11): no treatment was given; and another 12 normal term delivery women were served as control. Magnesium concentration levels were determined in both maternal peripheral blood and their fetal umbilical vein. Results Maternal serum magnesium level was higher in Group 2 (1.06±0.09) mmol/L than that in Group 1 (0.69±0.05) mmol/L (P<0.05), while there was no significant difference between Group 1 and Group 3. The serum magnesium levels in both mother and fetal umbilical ve

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