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卵巢正常大小的原发性卵巢上皮性癌综合征的临床特点与预后影响因素 |
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王纯雁 李联昆 祁秀峪 邹俊芝 侯进忠
【摘要】 目的 探讨卵巢正常大小的原发性卵巢上皮性癌综合征的临床特点及预后因素。方法 对10例患者的病例资料采用回顾性分析方法。结果 本病多发生于50岁以上，占80％；以腹胀、食欲差为首发症状，占90％；就诊晚，易误诊，误诊率40％；卵巢均正常大小，盆腹腔有广泛种植，局部聚集成块，占70％；术后残留灶直径<2.0 cm患者的生存时间高于术后残留灶直径≥2.0 cm者，但差异无显著性(P>0.05)。化学治疗疗程数≥6个者生存时间明显高于疗程数<6个者(P<0.05)。本组患者中位生存时间20个月，2年存活率50％；3年存活率30％；5年存活率20％。结论 术后残留灶大小可能是影响卵巢正常大小的原发性卵巢上皮性癌综合征患者预后的重要因素。术后系统化学治疗疗效显著。
【关键词】 卵巢肿瘤； 癌；预后
Analysis of the Clinical Characteristics and Prognostic Factors with Primary Normal-sized Epithelial Ovarian Carcinoma Syndrome
WANG Chunyan, LI Liankun, QI Xiuyu, et al.
（Department of Gynecology，Liaoning Tumor Hospital , Shenyang 110042，China）
【Abstract】 Objective To investigate the clinical characteristics and prognostic factors of the primary normal-sized epithelial ovarian carcinoma syndrome. Methods The clinical records and pathologic slides of the 10 patients who satisfied the diagnostic criteria were retrospectively analyzed. Results The primary normal-sized epithelial ovarian carcinoma syndrome was detected in approximately 1.92% of the patients with the epithelial ovarian carcinoma .The age of the patients at diagnosis ranged from 43～70 years, with a median age of 57 years. The most common presentations included anorexia, increasing abdominal girth and awareness of abdominal or pelvic mass. During the exploratory laparotomy although we often discovered the diffuse metastasis throughout the abdominal and pelvic cavity, the ovaries both appeared normal size and had a fine granularity on the external surface. The survival time of patients with remained tumors smaller than 2.0 cm was longer than those with remained tumors larger than 2.0 cm， but the Log-rank evaluation indicated χ2=0.61，P>0.05. The patients who underwent postoperative chemotherapy have been noted to achieve some long-term survival. The median survival time was 20 months. Conclusion The results predict that the size o[1] [2] 下一页
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